Produced in the mitochondria throughout the body from cholesterol,
pregnenolone is the base material of all human steroid manufacture,
including DHEA, progesterone, testosterone and estrogen. It appears
to block the effects of cortisol, preventing stress. Pregnenolone
stimulates brain NMDA receptors. These receptors, which decline
with age, play an important role in the function of synapses and
neurons, influencing learning and memory. Pregnenolone levels
are directly correlated with cognitive ability. Pregnenolone levels
decline with age.
Pregnenolone's anti-aging benefits may include reduction of stress,
reduction of arthritic inflammation, potential maintenance of
memory capability, improved mood, positive outlook and well-being
and improved sleep patterns.
Pharmacology: Chemical; 3-alpha-hydroxy-5-beta pregbeb-20-one.
Side Effects and Contraindications: There have been reports of
rash occurring with use, but otherwise there are few side effects.
There are no known contraindications, but people with prostate
conditions should be monitored carefully.
Distribution: Pregnenolone is available in 5mg, 10mg, 20mg, 25mg,
30mg, 50mg and 100mg capsules.
Note: Pregnenolone is set for a resurgence of interest and could
become more popular than DHEA.
to Anti-Aging Medicine Index