Anti Aging Today


Deprenyl is a drug that has been widely used to treat Parkinson's disease. In Parkinson's disease, dopamine, a major nerve transmitter, decreases due to the action of two enzymes, nonoamine oxidases (MAOS). MAO B occurs in the brain; MAO A occurs outside the brain and breaks up some amino acids present in food, thus serving a necessary purpose. Deprenyl inhibits only MAO B, and thus in combination with L-Dopa may be used to treat Parkinson's. Deprenyl may also act against several toxic chemicals produced when MAO B destroys dopamine and may act as an anti-depressant.

Deprenyl's anti-aging benefits may include improved memory, slowing of the loss of sexual capacity and increased life span.

A 1989 study conducted by Dr. J. Knoll showed that rats given Deprenyl beginning in their 24th month lived 30 percent longer than untreated rats. A 1990 study from the University of Toronto and McMaster University, on a different strain of rats, showed that treated rats lived 16 percent longer than controls. A 1991 study conducted by a group from Israel and Italy (Brandeis, Sapir, Kapon, Borelli, Cadel and Valsecchi) tested Deprenyl's effect on memory in aging rats and found that it improved the memories of both aging and young rats.

Side Effects and Contraindications: Side effects can include nausea, stomach ache, drowsiness and depression. High dosages can result in sudden high blood pressure spikes and agitation.

Distribution: Standard dosage for humans is 10mg/day. Deprenyl is sold in the U.S. for treatment of Parkinson's disease under the name Eldepryl.

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