ADRAFINIL

Adrafinil acts to stimulate brain activity only when stimulation is required. Modafinil is the latest, more potent analogue of Adrafinil. Both drugs act on brain Alpha 1 post synaptic receptors and make them more susceptible to norepinephrine, thus increasing alertness and concentration. They do not appear to affect other brain functions.

Adrafinil and Modafinil's anti-aging benefits have been increased and improved alertness and concentration, improved thought clarity and short-term memory and increased reaction speed, including hand-and-eye coordination.

Pharmacology: Chemical Name: 2-(Diphenylmethyl) sulfinyl acetohydroxamic acid. Molecular Formula: C(15)H(15)NO(3)S. Molecular Weight: 289.4CAS Registry: 63547 13-7. Adrafinil is an alpha-adrenergic agonist chemically related to Modafinil. It is given by mouth as a CNS Stimulant in doses of 60mg to 1.2g daily.

Side Effects and Contraindications: Side effects include an increase in liver enzyme levels and, therefore, usage should be monitored. Other side effects include headaches, stomach pain, minor skin irritations, inner tension and mild agitation, or aggression. People with epilepsy, liver or kidney impairment, or those using tranquilizers, should avoid Adrafinil and Modafinil. Caution is advised, if used in combination with norepinephrine-stimulating agents such as Yohimbine.

Distribution: Adrafinil is supplied in 300mg tablets under the trade name Olmifon. Modafinil is supplied under the trade name Modiodal in 100mg tablets.

Notes: Modafinil is superior to Adrafinil in its action. However, most patients will usually experience improvement with Adrafinil. Modafinil is a very recent addition and is considerably more expensive than Adrafinil.

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