And Its Use In Medical Therapy
Ozone therapy is one of the most powerful and
versatile therapies known today. Extensive medical research on
ozone therapy has been done primarily in Europe. Through its mechanism
of action, ozone has beneficial effects on every part of the body.
The effects include:
1. Inactivation of bacteria, viruses and fungi:
Ozone disrupts the integrity of the bacterial cell envelope through
peroxidation of the phospholipids and lipoproteins. In fungi,
ozone inhibits cell growth at certain stages. With viruses, the
ozone oxidizes the viral capsid and disrupts the reproductive
cycle by interrupting the virus-to-cell contact with peroxidation.
Cells previously infected by viruses are more susceptible to destruction
by the peroxide produced through ozonolysis, because they have
weak enzyme coatings.
2. Enhancement of circulation: In circulatory
disease, a clumping of red blood cells hinders blood flow and
decreases oxygen absorption due to reduced surface area. There
is a decrease in red blood cell flexibility which prevents them
traveling down the tiniest capillaries, and blood viscosity increases.
With ozone therapy, clumping is reduced or eliminated and flexibility
is restored, along with oxygen carrying ability. Oxygenation of
the tissues increases as the arterial partial pressure increases,
and viscosity decreases. Ozone also oxidizes the plaque in arteries
allowing the removal of the breakdown products, unclogging vessels.
3. Stimulation of oxygen metabolism: Ozone causes
an increase in the red blood cell glycolysis rate. This leads
to the stimulation of 2.3-diphosphoglycerate which shifts the
oxyhemoglobin disassociation curve to the right. This leads to
an increase in the amount of oxygen released to the surrounding
tissues. There is a stimulation of the production of the enzymes
which act as free radical scavengers and cell wall protectors:
glutathione peroxidase, catalase and superoxide dismutase. Ozone
activates the Krebs cycle by enhancing oxidative decarboxylation
of pyruvate, stimulating production of ATP.
4. Dissolution of malignant tumors: Malignant
cells have an increased rate of glycolysis which leads to the
production of more lactic acid. With ozone therapy, there is a
significant decrease in lactate production, showing that the metabolism
is being inhibited. Tumor cells have a peroxide intolerance due
to insufficient glutathione peroxidase and catalase. Ozone is
thus able to oxidize the outer lipid layer of malignant cells
and destroy them through cell lysis.
5. Activation of the immune system: Ozone stimulates
the production of gamma interferon and interleukin-2 in the body.
From this there is a cascade of subsequent immunological reactions.
6. Formation of peroxides: Ozone reacts with
the unsaturated fatty acids of the lipid layer in cellular membranes,
forming hydro peroxides. Lipid peroxidation products include peroxyl
radicals, vital for killer cell action.
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